Save time, money, the environment…and get better gel results! SYBR Safe is a DNA stain that fluoresces with a bright green colour when excited with blue light. Like Ethidium Bromide, SYBR Safe binds specifically to the DNA double helix. However, unlike Ethidium Bromide, SYBR Safe has been engineered to be less mutagenic than Ethidium Bromide, making it much safer to use, particularly in the classroom.